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Minoxidil is a topical medication for treating hair loss. It’s available as a liquid and as a foam and is applied directly to affected areas of the scalp. Minoxidil doesn’t block DHT.
Finasteride and minoxidil are usually first line therapy for its treatment. Other options include topical or systemic spironolactone or flutamide , although they have a high incidence of feminising side effects and are better tolerated in female androgenic hair loss.
Alfatradiol, also known as 17α-estradiol and sold under the brand names Avicis, Avixis, Ell-Cranell Alpha, and Pantostin, is a weak estrogen and 5α-reductase inhibitor medication which is used topically in the treatment of pattern hair loss (androgenic alopecia or pattern baldness) in men and women.
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
The solution has 1 mole or 1 equiv Na +, 1 mole or 2 equiv Ca 2+, and 3 mole or 3 equiv Cl −. An earlier definition, used especially for chemical elements , holds that an equivalent is the amount of a substance that will react with 1 g (0.035 oz) of hydrogen , 8 g (0.28 oz) of oxygen , or 35.5 g (1.25 oz) of chlorine —or that will displace ...
5α-Reductase inhibitors such as finasteride and dutasteride are inhibitors of 5α-reductase, an enzyme that is responsible for the formation of DHT from testosterone. [154] DHT is between 2.5- and 10-fold more potent than testosterone as an androgen [ 155 ] and is produced in a tissue-selective manner based on expression of 5α-reductase. [ 156 ]
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