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In nuclear medicine, radioisotopes are used for diagnosis, treatment, and research. Radioactive chemical tracers emitting gamma rays or positrons can provide diagnostic information about internal anatomy and the functioning of specific organs, including the human brain.
Radioactive isotopes are used in medicine for both treatment and diagnostic scans. The most common isotope used in diagnostic scans is Technetium-99m, used in approximately 85% of all nuclear medicine diagnostic scans worldwide. It is used for diagnoses involving a large range of body parts and diseases such as cancers and neurological problems ...
Radiolabeling is not necessary for some applications. For some purposes, soluble ionic salts can be used directly without further modification (e.g., gallium-67, gallium-68, and radioiodine isotopes). These uses rely on the chemical and biological properties of the radioisotope itself, to localize it within the organism or biological system.
The most commonly used radioisotope in PET, 18 F, is not produced in a nuclear reactor, but rather in a circular accelerator called a cyclotron. The cyclotron is used to accelerate protons to bombard the stable heavy isotope of oxygen 18 O. The 18 O constitutes about 0.20% of ordinary oxygen (mostly oxygen-16), from which it is extracted.
With a short half-life of 8 days, this radioisotope is not of practical use in radioactive sources in industrial radiography or sensing. However, since iodine is a component of biological molecules such as thyroid hormones, iodine-131 is of great importance in nuclear medicine, and in medical and biological research as a radioactive tracer.
The radioactive properties of 99m Tc can be used to identify the predominant lymph nodes draining a cancer, such as breast cancer or malignant melanoma. This is usually performed at the time of biopsy or resection . 99m Tc-labelled filtered sulfur colloid or Technetium (99mTc) tilmanocept are injected intradermally around the intended biopsy site.
The other radioisotopes of iodine are never used in brachytherapy. The use of 131 I as a medical isotope has been blamed for a routine shipment of biosolids being rejected from crossing the Canada—U.S. border. [40] Such material can enter the sewers directly from the medical facilities, or by being excreted by patients after a treatment
Some radioisotopes are used in ionic or inert form without attachment to a pharmaceutical; these are also included. There is a section for each radioisotope with a table of radiopharmaceuticals using that radioisotope. The sections are ordered alphabetically by the English name of the radioisotope.
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