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In the case the catecholamines, however, the enzymes of degradation monoamine oxidase and catechol-O-methyl transferase, like the enzymes of synthesis, are intracellular. Not metabolism but uptake through cell membranes therefore is the primary means of their clearance from the extracellular space. The mechanisms were deciphered beginning in 1959.
Two catecholamines, norepinephrine and dopamine, act as neuromodulators in the central nervous system and as hormones in the blood circulation. The catecholamine norepinephrine is a neuromodulator of the peripheral sympathetic nervous system but is also present in the blood (mostly through "spillover" from the synapses of the sympathetic system).
The β-blockers are an immensely important class of drugs due to their high prevalence of use. The discovery of β-blockers reaches back to more than 100 years ago, when early investigators came up with the idea that catecholamines were binding selectively to receptor-like structures and that this was the cause of their pharmacological actions. [3]
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) antagonists and alpha-2 (α 2) agonists, which are used to treat high ...
Julius Axelrod (May 30, 1912 – December 29, 2004) [1] was an American biochemist.He won a share of the Nobel Prize in Physiology or Medicine in 1970 along with Bernard Katz and Ulf von Euler.
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Catecholaminergic means "related to catecholamines". The catecholamine neurotransmitters include dopamine , epinephrine (adrenaline), and norepinephrine (noradrenaline). A catecholaminergic agent (or drug ) is a chemical which functions to directly modulate the catecholamine systems in the body or brain.
Serafim Guimarães. Serafim Guimarães, full name Serafim Correia Pinto Guimarães, (born May 2, 1934) is a Portuguese physician and pharmacologist.With his colleague Walter Osswald (born 1928) he made the Department of Pharmacology, Medical Faculty of the University of Porto, a center of research on catecholamines and the sympathetic nervous system, especially their relation to blood vessels.