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Herpetic simplex keratitis is a form of keratitis caused by recurrent herpes simplex virus (HSV) infection in the cornea. [ 1 ] It begins with infection of epithelial cells on the surface of the eye and retrograde infection of nerves serving the cornea. [ 2 ]
Keratitis is a condition in which the eye's cornea, the clear dome on the front surface of the eye, becomes inflamed. [1] The condition is often marked by moderate to intense pain and usually involves any of the following symptoms: pain, impaired eyesight, photophobia (light sensitivity), red eye and a 'gritty' sensation. [ 2 ]
Herpetic whitlow typically involves the fingers or thumb, [7] herpes simplex keratitis involves the eye, [8] herpesviral encephalitis involves the brain, [9] and neonatal herpes involves any part of the body of a newborn, among others. [10] There are two types of herpes simplex virus, type 1 (HSV-1) and type 2 (HSV-2). [1]
Corneal ulcer, also called keratitis, is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. [ 1 ] [ 2 ] [ 3 ] It is a common condition in humans particularly in the tropics and in farming. [ 4 ]
Idoxuridine is mainly used topically to treat herpes simplex keratitis. [3] Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. [4] Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. [3]
Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, encephalitis, as well as other herpes simplex infections: Neuron (sensory ganglia) Close contact (oral or sexually transmitted infection) HHV-2: Herpes simplex virus-2 (HSV-2) α: Mucoepithelial
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Herpes simplex; Herpes zoster; Mumps; Infectious mononucleosis; Influenza; Cytomegalic inclusion disease; Pharyngoconjunctival fever (adenovirus 3) Epidemic keratoconjunctivitis (adenovirus 8) Human immunodeficiency virus (acquired immunodeficiency syndrome) Ebola [1] Rift Valley Fever [2] Dengue [3] Hantavirus [4