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Diagnosing EPM can be challenging because the signs can vary significantly from horse to horse, and the symptoms can be similar to those of other CNS diseases. The only way to definitively diagnose EPM is through post-mortem testing, but there are ways to exclude other diseases and establish a basis for the EPM diagnosis.
Neospora hughesi is an obligate protozoan apicomplexan parasite that causes myelitis and equine protozoal myeloencephalitis (EPM) in horses, and has only been documented in North America. [1] EPM is a neurological disease from lesions in the spinal cord , brain stem , or brain from parasites such as N. hughesi or Sarcocystis neurona . [ 2 ]
Early clinical signs of EPM include stumbling and frequent interference, which can often be mistaken for lameness of thoracic and/or pelvic limbs in horses. In horses, the disease often progresses gradually and includes clinical signs such as ataxia. In some horses mild clinical signs may herald a rapidly progressive disease course.
Ponazuril (), sold by Merial, Inc., [1] now part of Boehringer Ingelheim, [2] under the trade name Marquis (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.
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Additionally, horses with a hind limb lameness will tend to reduce the degree of leg use. To do so, some horses will reduce the contraction time of the gluteals on the side of the lame leg, leading to a "hip roll" or "hip dip" and appearance that the hip drops a greater degree on the side of the lame leg. [10]
A Georgia couple was sentenced to 100 years in prison without parole after adopting two boys and sexually abusing them. William and Zachary Zulock will each spend the rest of their lives behind ...
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