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A drug-eluting stent (DES) is a small mesh tube that is placed in the arteries to keep them open in the treatment of vascular disease.The stent slowly releases a drug to block cell proliferation (a biological process of cell growth and division), thus preventing the arterial narrowing that can occur after stent implantation.
A 2014 meta-analysis showed there may be improved mortality with second generation drug-eluting stents, which were not available during the COURAGE trial. [52] Medical societies have since issued guidelines as to when it is appropriate to perform percutaneous coronary intervention.
Cypher is a brand of drug-eluting coronary stent from Cordis Corporation, a Cardinal Health company. During a balloon angioplasty, the stent is inserted into the artery to provide a "scaffold" to open the artery.
A dual therapy stent is a coronary artery stent that combines the technology of an antibody-coated stent and a drug-eluting stent. [1] Currently, second-generation drug-eluting stents require long-term use of dual-antiplatelet therapy , which increases the risk of major bleeding occurrences in patients. [ 2 ]
Bare metal stents were found to cause in-stent restenosis as a result of neointimal hyperplasia and stent thrombosis, which led to the invention of drug-eluting stents with anti-proliferative drugs to combat in-stent restenosis. [1]
Meta-analysis published in 2023 suggests that CABG provides a consistent survival benefit over PCI with drug-eluting stents (DES). [56] Favaloro's work is fundamental to the history of graft selection. He established the use of bilateral ITAs as superior to vein grafts.
[17] [18] During the early 2000s, he examined the problem of DES (drug-eluting stents) late stent thrombosis, and reported on a trial related to this issue in 2006 in the Journal of the American College of Cardiology, as well as in European Heart Journal and Euro Intervention in 2007. [19]
Coronary stents are placed during a coronary angioplasty.The most common use for coronary stents is in the coronary arteries, into which a bare-metal stent, a drug-eluting stent, a bioabsorbable stent, a dual-therapy stent (combination of both drug and bioengineered stent), or occasionally a covered stent is inserted.
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