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p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5] [6] In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. [5] [6] The expression of PUMA is regulated by the tumor suppressor p53.
P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from an ancestor gene in unicellular life. [ 4 ] The ancestor gene functioned in germ line DNA protection early invertebrates. [ 5 ]
P53 causes cells to enter apoptosis and disrupt further cell division therefore preventing that cell from becoming cancerous (16). In the majority of cancers it is the p53 pathway that has become mutated resulting in lack of ability to terminate dysfunctional cells.
This suggests that p53 pathway could be effectively harnessed as a therapeutic intervention to trigger senescence and ultimately mitigate tumorigenesis. [4] p53 has been shown to have promising therapeutic relevance in an oncological context. In the 2007 Nature paper by Xue et al., RNAi was used to regulate endogenous p53 in a liver carcinoma ...
Brain abnormalities and certain genetic conditions can affect the development of the pituitary gland, which may impact the production of growth hormone in a fetus, she says.
The activity of the mammalian tumor suppressor p53 depends on levels of an isoform of p53, p44. In an experiment with transgenic mice that had an over-expression of p44, hyper-activation of IGF-1R occurred, which in turn led to accelerated aging and death. The mice also experienced neuronal death in areas of the brain related to memory ...
Today's Wordle Answer for #1273 on Friday, December 13, 2024. Today's Wordle answer on Friday, December 13, 2024, is BOXER. How'd you do? Next: Catch up on other Wordle answers from this week.