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When of gradual onset, symptoms may include loss of bladder control, mild lower abdominal pain, and a weak urine stream. [1] Those with long-term problems are at risk of urinary tract infections. [1] Causes include blockage of the urethra, nerve problems, certain medications, and weak bladder muscles. [1]
Solifenacin, sold as the brand name Vesicare [a] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). [1] [2] It may help with incontinence, urinary frequency, and urinary urgency.
Treatment options include conservative treatment, behavioral therapy, bladder retraining, [36] pelvic floor therapy, collecting devices (for men), fixer-occluder devices for incontinence (in men), medications, and surgery. [37] Both nonpharmacological and pharmacological treatments may be effective for treating UI in non-pregnant women. [16]
Bladder, breast, nasopharyngeal, non-small cell lung, ovarian and pancreatic cancer, lymphomas and inflammatory bowel disease. Myelosuppression, pulmonary toxicity, kidney failure (rare), haemolytic uraemic syndrome (rare), thrombotic thrombocytopenic purpura (rare), anaphylactoid reaction (rare), reversible posterior leucoencephalopathy ...
Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. [2] The frequent need to urinate may occur during the day, at night, or both. [4] Loss of bladder control (urge incontinence) may occur with this condition. [1]
The chemical structure of Solabegron, a β 3-adrenergic receptor agonist. Mirabegron is a selective β 3-AR agonist that affects the detrusor muscles of the urinary bladder.By stimulation of β 3-AR the contraction of the smooth muscles of the bladder is decreased and the bladder can store more volume of urine at a given time.
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