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  2. IgA nephropathy - Wikipedia

    en.wikipedia.org/wiki/IgA_nephropathy

    IgA nephropathy is the most common glomerulonephritis worldwide; the global incidence is 2.5/100,000 per year amongst adults. [1] Aggressive Berger's disease is on the NORD list of rare diseases. [2] Primary IgA nephropathy is characterized by deposition of the IgA antibody in the glomerulus.

  3. Henoch–Schönlein purpura - Wikipedia

    en.wikipedia.org/wiki/Henoch–Schönlein_purpura

    As with IgA nephropathy, serum levels of IgA are high in HSP and there are identical findings on renal biopsy; however, IgA nephropathy has a predilection for young adults while HSP is more predominant among children. Further, IgA nephropathy typically only affects the kidneys while HSP is a systemic disease.

  4. Nephritic syndrome - Wikipedia

    en.wikipedia.org/wiki/Nephritic_syndrome

    The symptoms at onset are very similar to IgA nephropathy and include abdominal pain, hematuria, edema, and oliguria. [ 18 ] Henoch–Schönlein purpura (HSP) - Often considered a systemic form of IgA nephropathy , Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis that is characterized by deposition of IgA antibody immune ...

  5. Sparsentan - Wikipedia

    en.wikipedia.org/wiki/Sparsentan

    Sparsentan was approved in the US under accelerated approval based on reduction of proteinuria. [1] [5] [12] In September 2024, the US FDA converted the conditional approval in the kidney disease IgA nephropathy (IgAN) into a full approval based on positive long-term confirmatory results from the PROTECT Study demonstrating that sparsentan significantly slowed kidney function decline over two ...

  6. Glomerulonephritis - Wikipedia

    en.wikipedia.org/wiki/Glomerulonephritis

    IgA nephropathy, also known as Berger's disease, is the most common type of glomerulonephritis, and generally presents with isolated visible or occult hematuria, occasionally combined with low grade proteinuria, and rarely causes a nephritic syndrome characterised by proteinuria, and visible blood in the urine. IgA nephropathy is classically ...

  7. File:IgA Nephropathy.webm - Wikipedia

    en.wikipedia.org/wiki/File:IgA_Nephropathy.webm

    English: What is IgA nephropathy? IgA nephropathy, sometimes called Berger disease, is a type of nephritic syndrome where abnormal IgA antibody is formed, which results in immune complex deposition in the glomerular mesangium, leading to kidney disease. This video covers the pathophysiology, signs and symptoms, and treatment of IgA nephropathy.

  8. Mesangial proliferative glomerulonephritis - Wikipedia

    en.wikipedia.org/wiki/Mesangial_proliferative_gl...

    IgA nephropathy is the most common cause of MesPGN. [3] It is thought abnormally glycosylated IgA form polymers and deposit in the mesangium. [3] Subsequently, IgA immune complexes bind to IgA receptors on mesangial cells and induce injury to mesangial cells through release of cytokines and growth factors that promote infiltration of leukocytes ...

  9. Thin basement membrane disease - Wikipedia

    en.wikipedia.org/wiki/Thin_basement_membrane_disease

    In IgA nephropathy, episodes of frank hematuria are more common, and a family history is less common. A kidney biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm.