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  2. CRISPR gene editing - Wikipedia

    en.wikipedia.org/wiki/CRISPR_gene_editing

    CRISPR can be used to suppress mutations which cause gain of function, and also to repair mutations causing loss of function in neurological disorders. [199] The gene editing tool has become a foothold in vivo application for assimilation of molecular pathways. CRISPR is unique to the development of solving neurological diseases for several ...

  3. He Jiankui genome editing incident - Wikipedia

    en.wikipedia.org/wiki/He_Jiankui_genome_editing...

    On 26 November 2018, The CRISPR Journal published ahead of print an article by He, Ryan Ferrell, Chen Yuanlin, Qin Jinzhou, and Chen Yangran in which the authors justified the ethical use of CRISPR gene editing in humans. [74] As the news of CRISPR babies broke out, the editors reexamined the paper and retracted it on 28 December, announcing:

  4. 3 Things You Need to Know if You Buy CRISPR ... - AOL

    www.aol.com/3-things-know-buy-crispr-144500442.html

    Image source: CRISPR Therapeutics. 2. Profitability remains elusive. There's some optimism that CRISPR Therapeutics is still in the early stages of a significant long-term opportunity.

  5. CRISPR-associated transposons - Wikipedia

    en.wikipedia.org/wiki/CRISPR-associated_transposons

    CRISPR-associated transposons or CASTs are mobile genetic elements that have evolved to make use of minimal CRISPR systems for RNA-guided transposition of their DNA. [1] Unlike traditional CRISPR systems that contain interference mechanisms to degrade targeted DNA, CASTs lack proteins and/or protein domains responsible for DNA cleavage. [ 2 ]

  6. CRISPR RNA - Wikipedia

    en.wikipedia.org/wiki/CRISPR_RNA

    CRISPR RNA or crRNA is a RNA transcript from the CRISPR locus. [1] CRISPR-Cas (clustered, regularly interspaced short palindromic repeats - CRISPR associated systems) is an adaptive immune system found in bacteria and archaea to protect against mobile genetic elements , like viruses , plasmids , and transposons . [ 2 ]

  7. CRISPR activation - Wikipedia

    en.wikipedia.org/wiki/CRISPR_activation

    See: Guide RNA, CRISPR. Complementary base pairing between the sgRNA and genomic DNA allows targeting of Cas9 or dCas9. A small guide RNA (sgRNA), or gRNA is an RNA with around 20 nucleotides used to direct Cas9 or dCas9 to their targets. gRNAs contain two major regions of importance for CRISPR systems: the scaffold and spacer regions.

  8. Smartwatch and fitness tracker bands have elevated levels of ...

    www.aol.com/lifestyle/smartwatch-fitness-tracker...

    Why is perfluorohexanoic acid bad? At baseline, perfluorohexanoic acid is a forever chemical. That means it can build up in the body, with Peaslee noting that perfluorohexanoic acid ...

  9. Prime editing - Wikipedia

    en.wikipedia.org/wiki/Prime_editing

    CRISPR/Cas9 edits rely on non-homologous end joining (NHEJ) or homology-directed repair (HDR) to fix DNA breaks, while the prime editing system employs DNA mismatch repair. This is an important feature of this technology given that DNA repair mechanisms such as NHEJ and HDR, generate unwanted, random insertions or deletions (INDELs). These are ...

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