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  2. Interferon gamma - Wikipedia

    en.wikipedia.org/wiki/Interferon_gamma

    Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]

  3. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    He later won the Nobel Prize in chemistry. Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing mass cultivation and purification from bacterial cultures [84] or derived from yeasts. Interferon can also be produced by recombinant mammalian cells. [85]

  4. Interferon gamma 5' UTR regulatory element - Wikipedia

    en.wikipedia.org/wiki/Interferon_gamma_5'_UTR...

    Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to ...

  5. IFNW1 - Wikipedia

    en.wikipedia.org/wiki/IFNW1

    3467 n/a Ensembl ENSG00000177047 n/a UniProt P05000 n/a RefSeq (mRNA) NM_002177 n/a RefSeq (protein) NP_002168 n/a Location (UCSC) Chr 9: 21.14 – 21.14 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon omega-1 is a protein that is encoded by the IFNW1 gene. Introduction Interferon omega-1 (IFN-ω) is a subtype of the Interferon type I family. The Interferon Type 1 family is made ...

  6. T helper cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_cell

    The T h cells receiving both signals of activation and proliferation will then become T h 0 (T helper 0) cells that secrete IL-2, IL-4 and interferon gamma (IFN-γ). The T h 0 cells will then differentiate into T h 1 or T h 2 cells depending on cytokine environment. IFN-γ drives T h 1 cell production while IL-10 and IL-4 inhibit T h 1 cell ...

  7. Interferon gamma receptor (IFNGR1) family - Wikipedia

    en.wikipedia.org/wiki/Interferon_gamma_receptor...

    The vaccinia virus interferon (IFN)-gamma receptor (IFN-gammaR), which is a 43 kDa soluble glycoprotein that is secreted from infected cells early during infection. IFN-gammaR from vaccinia virus, cowpox virus and camelpox virus exist naturally as homodimers , whereas the cellular IFN-gammaR dimerises only upon binding the homodimeric IFN-gamma.

  8. Interferon alpha-1 - Wikipedia

    en.wikipedia.org/wiki/Interferon_alpha-1

    n/a Ensembl ENSG00000197919 n/a UniProt P01562 n/a RefSeq (mRNA) NM_024013 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.44 – 21.44 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma ; MIM 147570) is produced ...

  9. Interferon type I - Wikipedia

    en.wikipedia.org/wiki/Interferon_type_I

    The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...