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Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
Aripiprazole is an effective add-on treatment for major depressive disorder; however, there is a greater rate of side effects such as weight gain and movement disorders. [ 31 ] [ 32 ] [ 33 ] The overall benefit is small to moderate and its use appears to neither improve quality of life nor functioning. [ 31 ]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
John Marshall used to enjoy running but after a serious reaction to antibiotics in 2017 he was left barely able to walk. The 51-year-old from Kirkcaldy says his health changed dramatically after ...
[4] [3] Although atypical antipsychotics are thought to be safer than typical antipsychotics, they still have severe side effects, including tardive dyskinesia (a serious movement disorder), neuroleptic malignant syndrome, and increased risk of stroke, sudden cardiac death, blood clots, and diabetes. Significant weight gain may occur. Critics ...
Bipolar disorder is a serious mental health condition affecting 2.8 percent of adults in the United States. It involves episodes of mania (extreme highs) and depression (intense lows).
The greater risk of serious side effects with antipsychotics is why, e.g., quetiapine was denied approval as monotherapy for major depressive disorder or generalized anxiety disorder, and instead was only approved as an adjunctive treatment in combination with traditional antidepressants. [66]
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