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Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the eye. It is an exudate rich in white blood cells , seen in the anterior chamber, usually accompanied by redness of the conjunctiva and the underlying episclera .
Hypopyon, or inflammatory cells in the anterior chamber of the eye may be present. [3] In endogenous endophthalmitis systemic signs and symptoms may be present, including fevers, chills, mental status changes, hypotension or other signs of sepsis. [3] 8-20% of endogenous endophthalmitis affect both eyes. [3]
[3] [4] Increased outflow or aqueous loss may occur following a glaucoma surgery, trauma, post-surgical wound leak from the eye, cyclodialysis cleft, tractional ciliary body detachment or retinal detachment. [3] Use of anti fibrosis drugs like mitomycin C during glaucoma surgery will increase the risk of hypotony maculopathy development. [2]
Symptoms include eye pain, eye redness, floaters and blurred vision, and ophthalmic examination may show dilated ciliary blood vessels and the presence of cells in the anterior chamber. Uveitis may arise spontaneously, have a genetic component, or be associated with an autoimmune disease or infection.
Hypotony has many causes including post-surgical wound leak from the eye, chronic inflammation within the eye including iridocyclitis, hypoperfusion, tractional ciliary body detachment or retinal detachment. [5] Eye inflammation, medications including anti glaucoma drugs, or proliferative vitreoretinopathy causes decreased production. [6]
Veligrotug helped 64% of patients, when adjusted for placebo rates, achieve at least a 2-millimeter reduction in eye bulging after 15 weeks of treatment, Viridian said.
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