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  2. Prokaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Prokaryotic_DNA_replication

    Prokaryotic DNA Replication is the process by which a prokaryote duplicates its DNA into another copy that is passed on to daughter cells. [1] Although it is often studied in the model organism E. coli, other bacteria show many similarities. [2] Replication is bi-directional and originates at a single origin of replication (OriC). [3]

  3. Postreplication repair - Wikipedia

    en.wikipedia.org/wiki/Postreplication_repair

    In this case, the term PRR would encompasses all processes that facilitate the replication of damaged DNA, including those that repair replication-induced double-strand breaks. Melanoma cells are commonly defective in postreplication repair of DNA damages that are in the form of cyclobutane pyrimidine dimers , a type of damage caused by ...

  4. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    Eukaryotes initiate DNA replication at multiple points in the chromosome, so replication forks meet and terminate at many points in the chromosome. Because eukaryotes have linear chromosomes, DNA replication is unable to reach the very end of the chromosomes. Due to this problem, DNA is lost in each replication cycle from the end of the chromosome.

  5. DNA re-replication - Wikipedia

    en.wikipedia.org/wiki/DNA_re-replication

    DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle. [1] Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers . [ 2 ]

  6. Cell division - Wikipedia

    en.wikipedia.org/wiki/Cell_division

    Cell division over 42. The cells were directly imaged in the cell culture vessel, using non-invasive quantitative phase contrast time-lapse microscopy. [38] In 2022, scientists discovered a new type of cell division called asynthetic fission found in the squamous epithelial cells in the epidermis of juvenile zebrafish.

  7. DNA replication stress - Wikipedia

    en.wikipedia.org/wiki/DNA_replication_stress

    The replication fork consists of a group of proteins that influence the activity of DNA replication. In order for the replication fork to stall, the cell must possess a certain number of stalled forks and arrest length. The replication fork is specifically paused due to the stalling of helicase and polymerase activity, which are linked together ...

  8. DNA mismatch repair - Wikipedia

    en.wikipedia.org/wiki/DNA_mismatch_repair

    DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.

  9. Proofreading (biology) - Wikipedia

    en.wikipedia.org/wiki/Proofreading_(Biology)

    The extent of proofreading in DNA replication determines the mutation rate, and is different in different species. [4] For example, loss of proofreading due to mutations in the DNA polymerase epsilon gene results in a hyper-mutated genotype with >100 mutations per Mbase of DNA in human colorectal cancers. [5]