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Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] Organophosphates are used as insecticides , medications, and nerve agents . [ 4 ] Symptoms include increased saliva and tear production, diarrhea , vomiting, small pupils , sweating, muscle tremors, and confusion. [ 2 ]
In the treatment of organophosphate toxicity, cholinesterase reactivators such as Pralidoxime reactivate inhibited AChE at peripheral nicotinic receptors.Since AChE mediates effects on both nicotinic and muscarinic receptors, cholinesterase reactivators are co-administered with muscarinic antagonists, primarily atropine.
Organophosphate insecticides are acetylcholinesterase inhibitors, which disrupt the transmission of nerve signals in exposed organisms, with fatal results. The risk of human death through organophosphate poisoning [32] was obvious from the start and led to efforts to lower toxicity against mammals while not reducing efficacy against insects ...
Organophosphate toxicity is classically associated with acetylcholinesterase inhibition. Acetylcholinesterase is an enzyme responsible for breaking down the neurotransmitter acetylcholine . Many organophosphates, especially those designed to act as nerve agents or pesticides, bind with the active site on acetylcholinesterase, preventing it from ...
The toxicity of sarin in humans is largely based on calculations from studies with animals. The lethal concentration of sarin in air is approximately 28–35 mg per cubic meter per minute for a two-minute exposure time by a healthy adult breathing normally (exchanging 15 liters of air per minute, lower 28 mg/m 3 value is for general population ...
Anyone who may have information about someone poisoning cats is asked to call the Westover Police Department at 304-296-6576. To truly work toward solving the community cat problem, Smyth said TNR ...
In severe cases, atropine may be used as an antidote to counteract the effects of carbamates on the nervous system. Pralidoxime, another antidote, can be considered to reactivate inhibited acetylcholinesterase enzymes, although this is often less important for carbamate poisoning than it is for organophosphate poisoning. [1]
More: Fears that someone is trying to poison cats in Green spark concern, outrage. On Feb. 23, the Summit County Sheriff's Office said it received a report of an individual placing bowls of ...