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Pathophysiology of obesity is the study of disordered physiological processes that cause, result from, or are otherwise associated with obesity. A number of possible pathophysiological mechanisms have been identified which may contribute in the development and maintenance of obesity.
Obesity; Silhouettes and waist circumferences representing optimal, overweight, and obese: Specialty: Endocrinology: Symptoms: Increased fat [1] Complications: Cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, osteoarthritis, depression [2] [3] Causes
Death rate from obesity, 2019. Obesity is a risk factor for many chronic physical and mental illnesses.. The health effects of being overweight but not obese are controversial, with some studies showing that the mortality rate for individuals who are classified as overweight (BMI 25.0 to 29.9) may actually be lower than for those with an ideal weight (BMI 18.5 to 24.9). [1]
Being overweight or having obesity may increase the risk of several diseases, such as diabetes, heart disease, and some cancers, and may lead to short- and long-term health problems during pregnancy. [2] Rates of obesity worldwide tripled from 1975 to 2016 to involve some 1.8 billion people and 39% of the world adult population. [3]
Overweight is defined as a BMI of 25 or more, thus it includes pre-obesity defined as a BMI between 25 and 29.9 and obesity as defined by a BMI of 30 or more. [ 4 ] [ 5 ] Pre-obese and overweight however are often used interchangeably, thus giving overweight a common definition of a BMI of between 25 and 29.9.
For starters, semaglutide prescriptions exploded within the period of declining obesity, spiking from 471,876 prescription fills in January 2021 to 2,555,308 in 2023.
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.
Central obesity is a key feature of the syndrome, as both a sign and a cause, in that the increasing adiposity often reflected in high waist circumference may both result from and contribute to insulin resistance. However, despite the importance of obesity, affected people who are of normal weight may also be insulin-resistant and have the ...