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Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
The study showed that sildenafil was effective at treating ED. Pfizer then proceeded to obtain Patent 2,163,446 [2] for the use of a range of compounds for the treatment of erectile dysfunction, even though sildenafil was the only compound in the patent that had been shown to be effective in doing so. The patent contained a number of claims:
1993: Viagra (a.k.a. Sildenafil – compound UK-92,480) synthesised by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. The press identified Peter Dunn and Albert Wood as the inventors of the drug; only Andrew Bell, David Brown and Nicholas Terrett are listed on the original composition of ...
Generic sildenafil (and brand-name Viagra) is a medication for the treatment of ED, Raynaud’s phenomenon, and pulmonary arterial hypertension. To understand how Viagra works, we need to look at ...
Sildenafil is a prototype of PDE5 inhibitors that Pfizer launched as Viagra. It was approved by the Food and Drug Administration (FDA) in 1998 as the first oral medicine for erectile dysfunction. Later, in the year 2005, it was approved for the treatment of pulmonary arterial hypertension. [ 2 ]
It looks like Pfizer's (NYS: PFE) Viagra won't have any little blue generic competition for a while. During a court case with Teva Pharmaceutical (NAS: TEVA) , Pfizer successfully defended its ...
Recreational Viagra use does happen, and while some men see harmless benefits from the active ingredient in the famous “little blue pill,” they’re still taking a significant risk every time ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.