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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Adverse drug reaction: palmoplantar erythrodysesthesia (acral erythema) Because circulating levels of estrogen increase in both cirrhosis and pregnancy, estrogen was thought to be the main cause for the increased vascularity. More recently, nitric oxide has also been implicated in the pathogenesis of palmar erythema. [5]
Calluses (plantar in right foot and medial in left foot) A callus (pl.: calluses) is an area of thickened and sometimes hardened skin that forms as a response to repeated friction, pressure, or other irritation. Since repeated contact is required, calluses are most often found on the feet and hands, but they may occur anywhere on the skin.
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Additionally, some people may develop palmar plantar erythrodysesthesia (PPE), characterized by skin eruptions on the palms of the hand or soles of the feet, swelling, pain, and erythema. [18] Due to these side effects and its red color, doxorubicin has earned the nickname "red devil" [24] [25] or "red death." [26]
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The pisiform bone is most recognizable as an unassuming palmar projection forming the heel of human hand. [2]The pisiform bone, along with the hamulus of the hamate, defines the medial boundary of the carpal tunnel [2] because the pisiform body acts as one of the four attachments points of the flexor retinaculum. [3]