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Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions ; the atropine is present to prevent drug abuse and overdose.
[2] [3] It is a fixed-dose combination of the medications diphenoxylate, as the hydrochloride, an antidiarrheal; and atropine, as the sulfate, an anticholinergic. [1] It is taken by mouth. [2] Onset is typically within an hour. [4] Side effects may include abdominal pain, angioedema, glaucoma, heart problems, feeling tired, dry mouth, and ...
At high doses there are strong CNS effects and the atropine at such high doses causes typical anticholinergic side effects, such as anxiety, dysphoria, and delirium. Excessive use or overdose causes constipation and can promote development of megacolon as well as classic symptoms of overdose including potentially lethal respiratory depression. [2]
By managing acute pain effectively, suzetrigine may help prevent it from developing into chronic pain without the danger of dependency, meeting a "major unmet need," noted Jianguo Cheng, MD, PhD ...
Read More: Patients Are Suing Over Alleged Side Effects of Weight-Loss Drugs. The group found that people taking the GLP-1 medications had a lower risk of a number of health conditions, including ...
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
"Snack on oatmeal, choose whole grain bread for sandwiches and include barley or quinoa as a side at dinner," Galati recommends. "Aim to make 3/4 of your grains whole grain, and choose the more ...
Side effects attributed to the atropine content (especially when taken in excess doses, or in children), include: flushing, dryness in many areas, urinary retention, insomnia, headache, anxiety, hyperthermia, and tachycardia. It is these side effects that make it undesirable for most patients to take higher amounts of the medicine.