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Doses of 10, 25, and 50 mg via intramuscular injection have been found to result in average maximal concentrations of 7, 28, and 50 ng/mL, respectively. [42] With intramuscular injection, a dose of 25 mg results in normal luteal phase serum levels of progesterone within 8 hours, and a 100 mg dose produces mid-pregnancy levels of 40 to 80 ng/mL ...
The prevalence of antithrombin deficiency is estimated at ~0.02 to 0.2% of the general population, and 1-5% of patients with venous thromboembolism. [6] There is an elevated risk of thrombosis, whereby 50% patients with AT deficiency were found to have venous thromboembolism by age 50. [6]
The EC 10 and EC 90 concentrations to induce 10% and 90% maximal responses are defined similarly. There is a wide range of EC 50 values of drugs; they are typically anywhere from nM to mM. Hence, it is often more practical to refer to the logarithmically transformed p EC 50 values instead of EC 50 , where
[76] [77] [1] [78] Inhibition of ovulation occurred in about 90% of women at a dose of 0.5 to 2 mg/day and in 100% of women at a dose of 3 mg/day. [79] The total endometrial transformation dose of drospirenone is about 50 mg per cycle, whereas its daily dose is 2 mg for partial transformation and 4 to 6 mg for full transformation.
Lisdexamfetamine is available as the dimesylate salt in the form of both oral capsules and chewable tablets. [7] A dose of 50 mg of lisdexamfetamine dimesylate is approximately equimolar to a 20 mg dose of dextroamphetamine sulfate or to 15 mg dextroamphetamine free-base in terms of the amount of dextroamphetamine contained.
The resin has a higher affinity for highly charged countercations, for example by Ca 2+ (calcium) in the case of water softening. Correspondingly, anion-exchange resins are typically provided in the form of chloride Cl −, which is a highly mobile counteranion. Counterions are used in phase-transfer catalysis.
The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-octanol and water. [1] K ow is also frequently referred to by the symbol P, especially in the English literature. It is also called n-octanol-water partition ratio. [2] [3] [4]
The concept of Ct was first proposed by Fritz Haber and is sometimes referred to as Haber's law, which assumes that exposure to 1 minute of 100 mg/m 3 is equivalent to 10 minutes of 10 mg/m 3 (1 × 100 = 100, as does 10 × 10 = 100). Some chemicals, such as hydrogen cyanide, are rapidly detoxified by the human body, and do not follow Haber's law.