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Progesterone pharmacokinetics by route [1] [2] Route Form Dose C max (ng/mL) T max (hours) t 1/2 (hours) Oral: Capsule: 200 mg: 4.3–11.7: 2–2.5? Sublingual: Tablet [a] 100 mg: 13.5: 1–4 ~6–7 Suspension: 100 mg: 17.6: 0.5–1? Vaginal: Tablet [a] 100 mg: 10.9: 6–7: 13.7 Capsule: 100 mg: 9.7: 1–3? Intramuscular injection: Oil solution ...
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45] Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
0.5–5 mg/day Various: Estrogen: SC implant: 50–200 mg every 6–24 mos Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks ...
[64] [65] It has also been marketed in the form of 100, 200, 250, 400, and 500 mg oral tablets; 500 and 1,000 mg oral suspensions; and as a 50 mg/mL microcrystalline aqueous suspension for intramuscular injection. [66] [67] A 100 mg/mL microcrystalline aqueous suspension for intramuscular injection was previously available as well. [64]
Available forms of progesterone [sources 1] [a] Route Form Dose Brand name Availability [b] Oral: Capsule: 100, 200, 300 mg: Prometrium [c] Widespread Tablet (SR) 200, 300, 400 mg: Dubagest SR [c] India Sublingual: Tablet: 10, 25, 50, 100 mg: Luteina [c] Europe [d] Transdermal: Gel [e] 1% (25 mg) Progestogel: Europe Vaginal: Capsule: 100, 200 ...
Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...