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Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the ...
The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. [6] RHD has sequence similarity to RHCE, RhAG, RhBG, and RhCG and these five genes constitute the Rh family. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE protein subunits. [7]
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
The gene codes for the RhD protein on the red blood cell membrane. D− individuals who lack a functional RHD gene do not produce the D antigen and may be immunized by D+ blood. [citation needed] The D antigen is a dominant trait. If both of a child's parents are Rh negative, the child will definitely be Rh negative.
Cell-free DNA can be used the determine the Rh antigen of the fetus when the mother is Rh negative. Blood is taken from the mother during the pregnancy, and using PCR, can detect the K, C, c, D, and E alleles of fetal DNA. This blood test is non-invasive to the fetus and is an easy way of checking antigen status and risk of HDN.
For example, the ColoGuard test may be used to screen people over 55 years old for colorectal cancer. [57] Cancer is a longtime-scale disease with various progression steps, molecular diagnostics tools can be used for prognosis of cancer progression. For example, the OncoType Dx test by Genomic Health can estimate risk of breast cancer.
Symptoms: Fever, multiple painful joints, involuntary muscle movements, erythema marginatum [1] Complications: Rheumatic heart disease, heart failure, atrial fibrillation, infection of the valves [1] Usual onset: 2–4 weeks after a streptococcal throat infection, age 5–14 years [2] Causes: Autoimmune disease triggered by pathogenic strains ...
19743 Ensembl ENSG00000112077 ENSMUSG00000023926 UniProt Q02094 Q9QUT0 RefSeq (mRNA) NM_000324 NM_011269 RefSeq (protein) NP_000315 NP_035399 Location (UCSC) Chr 6: 49.61 – 49.64 Mb Chr 17: 41.12 – 41.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Rh-associated glycoprotein (RHAG) is an ammonia transporter protein that in humans is encoded by the RHAG gene. RHAG has also ...