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Insulin was first used as a medication in Canada by Charles Best and Frederick Banting in 1922. [13][14] This is a chronology of key milestones in the history of the medical use of insulin. For more details on the discovery, extraction, purification, clinical use, and synthesis of insulin, see Insulin. 1921 Research on the role of pancreas in ...
Potassium nitrite (distinct from potassium nitrate) is the inorganic compound with the chemical formula K N O 2. It is an ionic salt of potassium ions K + and nitrite ions NO 2 −, which forms a white or slightly yellow, hygroscopic crystalline powder that is soluble in water. [1] It is a strong oxidizer and may accelerate the combustion of ...
Insulin shock therapy or insulin coma therapy was a form of psychiatric treatment in which patients were repeatedly injected with large doses of insulin in order to produce daily comas over several weeks. [ 1 ] It was introduced in 1927 by Austrian-American psychiatrist Manfred Sakel and used extensively in the 1940s and 1950s, mainly for ...
For treatment of diabetes insipidus, see Diabetes insipidus. Drugs used in diabetes treat diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral ...
Insulin is a peptide hormone containing two chains cross-linked by disulfide bridges. Insulin (/ ˈɪn.sjʊ.lɪn /, [ 5 ][ 6 ] from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. It is the main anabolic hormone of the body. [ 7 ]
Intensive insulin therapy or flexible insulin therapy is a therapeutic regimen for diabetes mellitus treatment. This newer approach contrasts with conventional insulin therapy. Rather than minimize the number of insulin injections per day (a technique which demands a rigid schedule for food and activities), the intensive approach favors ...
The insulin transduction pathway is a biochemical pathway by which insulin increases the uptake of glucose into fat and muscle cells and reduces the synthesis of glucose in the liver and hence is involved in maintaining glucose homeostasis. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other hormones.
Alpha-glucosidase inhibitor. Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar). Carbohydrates are normally converted into simple sugars (monosaccharides) by alpha-glucosidase enzymes present on cells lining ...
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