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Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis , psoriasis , Crohn's disease , nephrotic syndrome , eczema , and in organ transplants to prevent rejection .
Ciclosporin is thought to bind to the cytosolic protein cyclophilin (an immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin , which under normal circumstances induces the transcription of interleukin-2 .
Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. [1] It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis , [ 2 ] rheumatoid arthritis , [ 3 ] dry eye [ 4 ] and other auto-immune related conditions.
Download QR code; Print/export Download as PDF; Printable version; In other projects ... Cyclosporin A (ciclosporin) Cyclosporin B; Cyclosporin C; Cyclosporin D ...
A biosafety level (BSL), or pathogen/protection level, is a set of biocontainment precautions required to isolate dangerous biological agents in an enclosed laboratory facility. The levels of containment range from the lowest biosafety level 1 (BSL-1) to the highest at level 4 (BSL-4).
Voclosporin, sold under the brand name Lupkynis, is a calcineurin inhibitor used as an immunosuppressant medication for the treatment of lupus nephritis. [2] [4] It is an analog of ciclosporin that has enhanced action against calcineurin and greater metabolic stability.
We have not found a clinical use for routine hormone levels that justifies the expense. However, we recognize that individual providers may adjust their prescribing and monitoring practices as needed to comply with guidelines or when guided by patient need." [5] International Planned Parenthood Federation (IPPF) United Kingdom <200 pg/mL: 30 ...
This is a good page, is there any objection to moving it to the INN ciclosporin and having cyclosporine redirect there? Let "ciclosporin" redirect to cyclosporine which is the compounds real name. Cacycle 21:13, 21 Dec 2004 (UTC) In accordance with Wikipedia:WikiProject_Drugs naming policy, I propose we move this page to the INN ciclosporin.