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Propargylamine is an organic compound with the formula HC≡CCH 2 NH 2.It is a colorless, odorless liquid that is used as a precursor to other compounds. [1] Propargyl amines are produced by reactions of amines with propargyl halides.
In organic chemistry, the propargyl group is a functional group of 2-propynyl with the structure CH≡C−CH 2 −. It is an alkyl group derived from propyne ( HC≡C−CH 3 ). The term propargylic refers to a saturated position ( sp 3 -hybridized ) on a molecular framework next to an alkynyl group.
Propargyl bromide is an alkylating agent. For example, it reacts with dimethylsulfide, it reacts to give the sulfonium salt: [4] HCCCH 2 Br + S(CH 3) 2 → [HCCCH 2 S(CH 3) 2]Br. It alkylates even weakly basic amines such as aniline. [5] Aldehydes react with propargyl bromide in a Barbier-type reaction to yield alkynyl alcohols: [6]
Density: 1.1325 g/cm 3: Melting point: 9 °C (48 °F; 282 K) Boiling point: ... It is prepared commercially by oxidizing propargyl alcohol at a lead electrode. [6]
They convert polar compounds into less polar more volatile derivatives. In this way, chloroformates enable relatively simple transformation of large array of metabolites (aminoacids, amines, carboxylic acids, phenols) for analysis by gas chromatography / mass spectrometry. [1]
The 2-propynyl group is also known as a propargyl group, and has the structure HC≡C−CH 2 –R. [3] References
A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry.This group consists of three methyl groups bonded to a silicon atom [−Si(CH 3) 3], which is in turn bonded to the rest of a molecule.
Rasagiline, also known as (R)-N-propargyl-1-aminoindan and by its former developmental code name TVP-1012, is a secondary cyclic benzylamine propargylamine. [ 1 ] [ 55 ] It is the R (+)- enantiomer of the chiral racemic compound AGN-1135 ( N -propargyl-1-aminoindan), whereas the S (–)-enantiomer is TVP-1022 (( S )- N -propargyl-1-aminoindan).