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Damage to the frontal lobe can cause increased irritability, which may include a change in mood and an inability to regulate behavior. [1] Particularly, an injury of the frontal lobe could lead to deficits in executive function, such as anticipation, goal selection, planning, initiation, sequencing, monitoring (detecting errors), and self ...
The prefrontal cortex has been defined based on cytoarchitectonics by the presence of a cortical granular layer IV.It is not entirely clear who first used this criterion. Many of the early cytoarchitectonic researchers restricted the use of the term prefrontal to a much smaller region of cortex including the gyrus rectus and the gyrus rostralis (Campbell, 1905; G. E. Smith, 1907; Brodmann ...
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. [5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production.
The prefrontal cortex is also physically affected by cocaine use. Chronic use has been shown to lead to a decrease in the amount of gray matter in the ventromedial prefrontal cortex. The decrease in gray matter and effect on behavior is analogous to a person having lesions throughout their medial prefrontal cortex. [35]
A 2015 review concluded that "Nicotine acts as a gateway drug on the brain, and this effect is likely to occur whether the exposure is from smoking tobacco, passive tobacco smoke or e-cigarettes." [25] Nicotine may have a profound impact on sleep. [26] The effects on sleep vary after being intoxicated, during withdrawal, and from long-term use ...
Alcohol-related brain damage [1] [2] alters both the structure and function of the brain as a result of the direct neurotoxic effects of alcohol intoxication or acute alcohol withdrawal. Increased alcohol intake is associated with damage to brain regions including the frontal lobe , [ 3 ] limbic system , and cerebellum , [ 4 ] with widespread ...
Genetic factors include abnormalities in the prefrontal cortex of the brain while neurobiological risk include maternal drug use during pregnancy, birth complications, low birth weight, prenatal brain damage, traumatic head injury, and chronic illness. [2]
[51] [52] As in the case of Michael below, damage to the orbitofrontal cortex has been linked to antisocial and criminal behavior. [53] [54] Damage to the ventromedial prefrontal cortex has been linked to antisocial behavior, poor and amoral decision making, and reduced autonomic response to emotionally arousing stimuli. [55]