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Testosterone promotes prostate cell proliferation, [26] but relatively low levels of serum testosterone are found in patients with BPH. [ 27 ] [ 28 ] One small study has shown that medical castration lowers the serum and prostate hormone levels unevenly, having less effect on testosterone and dihydrotestosterone levels in the prostate.
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
Prostate cells contain an Androgen Receptor (AR), that when stimulated by androgens like testosterone, promotes growth and maintains prostatic differentiation. These pro-growth signals, however, can be problematic when they occur in a cancer cell.
Psychological factors like stress and anxiety can lower a person’s libido, no matter how robust their levels of testosterone, estrogen, or any other biological element may be. So can social ...
Recent studies reveal that diets rich in omega-3 fatty acids, particularly DHA, may slow down prostate cancer growth, while diets that promote inflammation might increase the risk of aggressive ...
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The net result is that testosterone and its metabolite together are not tissue selective. [26] SARMs are not substrates of 5α-reductase, hence they are not selectively activated like testosterone in tissues such as prostate. [10] This lack of activation effectively imparts a degree of tissue selectivity to SARMs. [27]
Testosterone therapy for patients with late-onset hypogonadism, in addition to increasing risk of cardiovascular disease and prostate cancer, may exacerbate the risk factors associated with benign prostatic hyperplasia, a condition that involves the noncancerous enlargement of the prostate gland, which can lead to urinary symptoms.
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