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The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-octanol and water. [1] K ow is also frequently referred to by the symbol P, especially in the English literature. It is also called n-octanol-water partition ratio. [2] [3] [4]
The partition coefficient between n-Octanol and water is known as the n-octanol-water partition coefficient, or K ow. [62] It is also frequently referred to by the symbol P, especially in the English literature. It is also known as n-octanol-water partition ratio. [63] [64] [65]
Coefficients for partition between given gas phase and solvent wet/dry solvent c e s a b l source w Butan-1-ol -0.095 0.262 1.396 3.405 2.565
Bioconcentration factors can also be related to the octanol-water partition coefficient, K ow. The octanol-water partition coefficient (K ow) is correlated with the potential for a chemical to bioaccumulate in organisms; the BCF can be predicted from log K ow, via computer programs based on structure activity relationship (SAR) [7] or through ...
The distribution of a compound between water and octanol is used to calculate the partition coefficient, P, of that molecule (often expressed as its logarithm to the base 10, log P). Water/octanol partitioning is a relatively good approximation of the partitioning between the cytosol and lipid membranes of living systems. [5]
The descriptor most often used in QSAR to determine the hydrophobicity of a compound is the octanol-water partition coefficient, log P. [16] MLC provides an attractive and practical alternative to QSAR. When micelles are added to a mobile phase, many similarities exist between the micellar mobile phase/stationary phase and the biological ...
Partition coefficients are very important in pharmacology because they determine the extent to which a substance can pass from the blood (an aqueous solution) through a cell wall which is like an organic solvent. They are usually measured using water and octanol as the two solvents, yielding the so-called octanol-water partition coefficient.
The ratio gives the relative hydrophobicity scale for individual amino acids. Computation was trained on high resolution protein crystal structures. This quantitative descriptor for microenvironment was derived from the octanol-water partition coefficient, (known as Rekker's Fragmental Constants) widely used for pharmacophores. This scale well ...
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