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The average dose necessary for effective antitussive therapy is between 10 and 45 mg, depending on the individual. The International Society for the Study of Cough recommends "an adequate first dose of medication is 60 mg in the adult and repeat dosing should be infrequent rather than qds recommended." [39]
In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17]
In Study 1 (GEMINI), a 6-week randomized controlled trial of dextromethorphan/bupropion versus placebo in people with major depressive disorder, scores on the Montgomery–Åsberg Depression Rating Scale (MADRS)—a scale with a range of 0 to 60 points—decreased with dextromethorphan/bupropion by 15.9 points from a baseline score of 33.6 ...
The CDC’s new COVID-19 vaccine recommendations suggest a second dose of the updated COVID-19 vaccine for people who are 65+, as well as those who are moderately or severely immunocompromised ...
On November 21, 2021, 90% of the target population had been fully vaccinated, while around 1 in 5 people had received a booster on top of that; [3] by December 9, 2021, the share of the population having received a booster shot exceeded 50%. [4] On December 13, 2021, the country began offering Pfizer vaccinations to children aged 5–11. [5]
According to the official statistics of 6 September 2021, 7.6% of people over the age of 80 had received at least one dose of the vaccine, for people aged 40–59 this figure was slightly more than 19% and the most vaccinated group was people aged 18–19 years of whom 19.8% had received at least one dose of vaccine. [3]
"At some point, I knew this was going to happen, but I always take the high road," Dončić said. "I had my amazing moments in Dallas with my teammates, coaches and, most importantly, the fans.
The researchers discovered that people who took vitamin D had a 40% lower risk of developing dementia than those who didn’t take a supplement. They also had a 15% higher five-year survival rate.