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N-Methylmaleimide (NMM) is a naturally-occurring [citation needed] organic compound with the formula of C 5 H 5 NO 2. Spectrum. The 1 H NMR spectrum of N ...
Maleimide-mediated methodologies are among the most used in bioconjugation. [5] [6] Due to fast reactions and high selectivity towards cysteine residues in proteins, a large variety of maleimide heterobifunctional reagents are used for the preparation of targeted therapeutics, assemblies for studying proteins in their biological context, protein-based microarrays, or proteins immobilisation. [7]
N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the amide functional group , but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides .
N-Methylmaleimide This page was last edited on 17 March 2021, at 20:13 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 License ...
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AMG-517 is a drug which acts as a potent and selective blocker of the TRPV1 ion channel. [1] [2] It was developed as a potential treatment for chronic pain, but while it was an effective analgesic in animal studies it was dropped from human clinical trials at Phase I due to producing hyperthermia as a side effect, as well as poor water solubility.
N-Methylmorpholine N-oxide (more correctly 4-methylmorpholine 4-oxide), NMO or NMMO is an organic compound.This heterocyclic amine oxide and morpholine derivative is used in organic chemistry as a co-oxidant and sacrificial catalyst in oxidation reactions for instance in osmium tetroxide oxidations and the Sharpless asymmetric dihydroxylation or oxidations with TPAP. [1]