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20437 Ensembl ENSG00000196470 ENSMUSG00000036840 UniProt Q8IUQ4 P61092 RefSeq (mRNA) NM_001006610 NM_003031 NM_001006611 NM_009172 RefSeq (protein) NP_001006611 NP_003022 NP_033198 Location (UCSC) Chr 16: 48.36 – 48.45 Mb Chr 8: 87.45 – 87.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene ...
At the start of the ubiquitination cascade, the E1 enzyme (Figure 2) binds ATP-Mg 2+ and ubiquitin and catalyses ubiquitin C-terminal acyl adenylation. [4] In the next step a catalytic cysteine (Figure 3) on the E1 enzyme attacks the ubiquitin-AMP complex through acyl substitution, simultaneously creating a thioester bond and an AMP leaving group. [2]
6500 21402 Ensembl ENSG00000113558 ENSMUSG00000036309 UniProt P63208 Q9WTX5 RefSeq (mRNA) NM_170679 NM_006930 NM_011543 RefSeq (protein) NP_008861 NP_733779 NP_035673 Location (UCSC) Chr 5: 134.15 – 134.18 Mb Chr 11: 52.12 – 52.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene. This gene ...
The S1 domain is a protein domain that was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel.
The protein binds to hemi-methylated DNA during S-phase and recruits the main DNA methyltransferase protein, DNMT1, to regulate chromatin structure and gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle .
79594 68350 Ensembl ENSG00000090432 ENSMUSG00000041241 UniProt Q969V5 Q8VCM5 RefSeq (mRNA) NM_024544 NM_026689 RefSeq (protein) NP_078820 NP_080965 Location (UCSC) Chr 1: 20.5 – 20.51 Mb Chr 4: 138.16 – 138.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1 ...
Nuclease S1 (EC 3.1.30.1) is an endonuclease enzyme that splits single-stranded DNA (ssDNA) and RNA into oligo- or mononucleotides. This enzyme catalyses the following chemical reaction Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products
Originally thought as an intracellular second messenger, it was discovered to be an extracellular ligand for G protein-coupled receptor S1PR1 in 1998. It is now known that sphingosine-1-phosphate receptors (S1P receptors) are members of the lysophospholipid receptor family. There are five described to date.