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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
CA-125: Mainly ovarian cancer, [12] but may also be elevated in for example endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. [13] Calcitonin: medullary thyroid carcinoma [14] Calretinin: mesothelioma, sex cord-gonadal stromal tumor, adrenocortical carcinoma, synovial sarcoma [8] Carcinoembryonic ...
CA-125 levels are not accurate in early stage ovarian cancer, as half of stage I ovarian cancer patients have a normal CA-125 level. [31] [29] CA-125 may also be elevated in benign (non-cancerous) conditions, including endometriosis, pregnancy, uterine fibroids, menstruation, ovarian cysts, systemic lupus erythematosus, liver disease ...
The CA-125 marker in children and adolescents can be frequently elevated even in absence of malignancy and conservative management should be considered. Polycystic ovarian syndrome involves the development of multiple small cysts in both ovaries due to an elevated ratio of leutenizing hormone to follicle stimulating hormone , typically more ...
CA-125: Ovarian cancer: MUC-1: Breast cancer: Epithelial tumor antigen (ETA) Breast cancer: Tyrosinase: Malignant melanoma: normally present in minute quantities; greatly elevated levels in melanoma Melanoma-associated antigen (MAGE) Malignant melanoma: Also normally present in the testis: abnormal products of ras, p53: Various tumors
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The results of this trial demonstrated a stable disease for 10/18 patients ( 56%) and had no immunogenic response. M5A-DOTA was coupled with 225-Ac , which is an alpa emitter, and an in vivo study was performed where cytokine therapy was combined with a-therapy. [30] The result of the study revealed the benefit of combining these two treamtents.
The Oakland Unified School District, California's 11th-largest public school district, said in a letter to families that it had tested over 1,000 faucets and fountains at 40 TK-12 schools to ...