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It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL. The reaction is characterized by the on-rate constant k on and the off-rate constant k off, which have units of M −1 s −1 and s −1, respectively. In equilibrium, the forward binding transition R + L → ...
The binding problem refers to the overall encoding of our brain circuits for the combination of decisions, actions, and perception. It is considered a "problem" due to the fact that no complete model exists. The binding problem can be subdivided into the four areas of perception, neuroscience, cognitive science, and the philosophy of mind. It ...
Receptor–ligand binding kinetics also involves the on- and off-rates of binding. A main goal of receptor–ligand kinetics is to determine the concentrations of the various kinetic species (i.e., the states of the receptor and ligand) at all times, from a given set of initial concentrations and a given set of rate constants.
The dissociation rate constant is defined using K off. [2] The Michaelis-Menten constant is denoted by K m and is represented by the equation K m = (K off + K cat)/ K on [definition needed]. The rates that the enzyme binds and dissociates from the substrate are represented by K on and K off respectively.
The Scatchard equation is an equation used in molecular biology to calculate the affinity and number of binding sites ... (k off) related to the dissociation constant ...
The binding potential is then the ratio ligand-receptor complex to free ligand at equilibrium and in the limit of L tending to 0, and is given symbol BP: = | This quantity, originally defined by Mintun, [1] describes the capacity of a receptor to bind ligand. It is a limit (L << Ki) of the general receptor association equation:
The symbol grounding problem is a concept in the fields of artificial intelligence, cognitive science, philosophy of mind, and semantics.It addresses the challenge of connecting symbols, such as words or abstract representations, to the real-world objects or concepts they refer to.
In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex. There are two main kinds of complex: compounds formed by the ...