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An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body. [ citation needed ]
A hilar cell tumor is an androgen-producing ovarian tumor that is most commonly found in older women and often leads to the development of male sex characteristics. The tumor tends to occur around the region of the ovary where the blood vessels enter the organ, known as the hilum. This type of tumor tends to be small in size and in most cases ...
Sertoli–Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group [2] of ovarian and testicular cancers. The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. [ 1 ]
The majority of Leydig cell tumors are found in males, usually at 5–10 years of age or in middle adulthood (30–60 years). Children typically present with precocious puberty. [citation needed] Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization.
The tumor forms in the ovaries and gradually spreads to the outside of ovary. This mostly affects younger women and also hinders the reproductive system. [7] Causes: Causes are debatable and these may occur to both pregnant women and women who do not opt for pregnancy Symptoms: [citation needed] Abdominal pain or swelling. Bowel problems or ...
The term "adrenogenital syndrome" was applied to both sex-steroid producing tumors and severe forms of CAH for much of the 20th century, before some of the forms of CAH were understood. Congenital adrenal hyperplasia, which also dates to the first half of the century, has become the preferred term to reduce ambiguity and to emphasize the ...
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone [27] [28] [29] CAH is a genetic disorder characterized by impaired production of cortisol in the adrenal glands.
Androgen-secreting tumors: Tumors in the adrenal glands or in the ovaries leading to increase levels of androgens. [19] Rapid progression and virilization symptoms. [14] Other less common hormonal causes: Acromegaly: Elevated levels of insulin-like growth factor-1. [18] Hyperthyroidism or hypothyroidism: Elevated or decreased levels of thyroid ...