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Lupron injection was approved by the FDA for treatment of advanced prostate cancer on 9 April 1985. [ 45 ] [ 4 ] [ 43 ] [ 44 ] Lupron depot for monthly intramuscular injection was approved by the FDA for palliative treatment of advanced prostate cancer on 26 January 1989.
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
Lupron Depot: This is a drug delivery device that helps treat prostate cancer and has been used to treat other types of similar cancers. It is also known as leuprorelin or leuprolide. PLGA is used as a key component in this drug, in the form of microparticles to deliver the drug into the body over a period of 1 week to 6 months. [15]
Endo International creates histerelin acetate (Vantas) while AbbVie manufactures leuprolide acetate (Lupron Depot). [ 57 ] [ 58 ] Other companies within the United States are also in the mix such as Pfizer who distributes histerelin acetate (Supprelin LA) and Tolmar Pharmaceuticals who create their own leuprolide acetate (Fensolvi).
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[28] [29] GnRH agonists commonly used are leuprorelin, goserelin, and triptorelin, which are marked as Lupron, Zoladex, and Decapetyl, respectively. [30] Nafarelin, marked as Synarel, is also occasionally prescribed in the form of nasal spray. [31] These drugs are all approved by the US FDA, and their working principles target both sexes equally.
The man responsible for a deadly truck attack on Bourbon Street in New Orleans has been identified as Shamsud-Din Jabbar, a 42-year-old U.S.-born citizen from Texas, the FBI said. He was a U.S ...
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