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Lupron injection was approved by the FDA for treatment of advanced prostate cancer on 9 April 1985. [ 45 ] [ 4 ] [ 43 ] [ 44 ] Lupron depot for monthly intramuscular injection was approved by the FDA for palliative treatment of advanced prostate cancer on 26 January 1989.
A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
Lupron Depot: This is a drug delivery device that helps treat prostate cancer and has been used to treat other types of similar cancers. It is also known as leuprorelin or leuprolide. PLGA is used as a key component in this drug, in the form of microparticles to deliver the drug into the body over a period of 1 week to 6 months. [15]
Romanian nationals Laurentiu Baceanu and Alexandru Vasile are accused of posing as law enforcement during a series of robberies in Orange County, including in Anaheim, Tustin and Westminster.
[28] [29] GnRH agonists commonly used are leuprorelin, goserelin, and triptorelin, which are marked as Lupron, Zoladex, and Decapetyl, respectively. [30] Nafarelin, marked as Synarel, is also occasionally prescribed in the form of nasal spray. [31] These drugs are all approved by the US FDA, and their working principles target both sexes equally.
Later in the 1980s, the Lupron Depot technology further advanced the field by offering zero-order and long-term release systems. The intranasal route gained interest towards the end of the 20th century with treating cardiovascular and respiratory diseases.
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