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A mouse-human hybrid is a genetically modified mouse whose genome has both mouse and human genes, thus being a murine form of a human-animal hybrid. For example, genetically modified mice may be born with human leukocyte antigen genes in order to provide a more realistic environment when introducing human white blood cells into them in order to ...
The gene targeting method in knockout mice uses mouse embryonic stem cells to deliver artificial genetic material (mostly of therapeutic interest), which represses the target gene of the mouse by the principle of homologous recombination. The mouse thereby acts as a working model to understand the effects of a specific mammalian gene.
The mouse HoxA cluster shown here has 11 paralogous genes (2 are missing). [39] Paralogous genes can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals. These genes not only underwent gene duplications within chromosomes but also whole genome duplications. As ...
18091 Ensembl ENSG00000183072 ENSMUSG00000015579 UniProt P52952 P42582 RefSeq (mRNA) NM_004387 NM_001166175 NM_001166176 NM_008700 RefSeq (protein) NP_001159647 NP_001159648 NP_004378 NP_032726 Location (UCSC) Chr 5: 173.23 – 173.24 Mb Chr 17: 27.06 – 27.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2 ...
This is an indispensable tool for any researcher using the mouse as a model organism for their research, and for researchers interested in genes that share homology with the mouse genes. Various mouse research support resources including animal collections and free colony management software are also available at the MGI site. [7]
This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. The laboratory mouse genome has been sequenced and many mouse genes have human homologues. [1]
240411 Ensembl ENSG00000167210 ENSMUSG00000032818 UniProt Q8IVV2 C8YR32 RefSeq (mRNA) NM_001145472 NM_001145473 NM_001173129 NM_001308013 NM_144612 NM_001384474 NM_172834 RefSeq (protein) NP_001138944 NP_001138945 NP_001166600 NP_001294942 NP_653213 NP_766422 Location (UCSC) Chr 18: 46.48 – 46.66 Mb Chr 18: 77.37 – 77.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ...
Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. [6] The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. [6] GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.