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Lasmiditan is a serotonin receptor agonist that, like the unsuccessful LY-334,370, selectively binds to the 5-HT 1F receptor subtype. A number of triptans have been shown to act on this subtype as well, but only after their affinity for 5-HT 1B and 5-HT 1D has been made responsible for their anti-migraine activity.
Patients with secondary Raynaud's can also have symptoms related to their underlying diseases. Raynaud's phenomenon is the initial symptom that presents for 70% of patients with scleroderma, a skin and joint disease. [citation needed] When Raynaud's phenomenon is limited to one hand or one foot, it is referred to as unilateral Raynaud's.
While most junk email can seem like a minor annoyance, certain types of email can cause problems for not only you but other people you email. Sometimes these emails can contain dangerous viruses or malware that can infect your computer by downloading attached software, screensavers, photos, or offers for free products.
The term Raynaud's does this and is the term used by the NIH. This ref specifically says "People who have primary Raynaud's (Raynaud's disease) or secondary Raynaud's (Raynaud's phenomenon)" Doc James (talk · contribs · email) 17:36, 1 October 2016 (UTC) Support this is the ICD10 preferred name. We and all medical naming conventions are ...
The coexistence of erythromelalgia and Raynaud's phenomenon is rare, but case studies of patients with both diagnoses have been reported in medical journals. [17] Symptoms may present gradually and incrementally, sometimes taking years to become intense enough for patients to seek medical care. In other cases symptoms emerge full blown with onset.
Some symptom management includes eating slower and taking smaller bites; in some cases medications can be useful to manage other issues that contribute to EMD such as a proton pump inhibitor to ease gastroesophageal reflux (acid reflux), or a smooth muscle relaxant for issues with the muscles.
The most prevalent skin change is Raynaud's phenomenon, which usually appears early in the course of the disease. [14] Swollen digits are a common sign, and on occasion, the complete hand swells. [15] [16] Acrosclerosis, also known as sclerodactyly, can develop with or without proximal scleroderma and is usually a later symptom of the condition ...
The Maria Duval scam is one of the most successful mail scams in history, having defrauded millions of people out of at least $200 million over twenty years. Targeting sick and elderly people through a combination of personalized letters and personal information databases, it has been shut down in the United States in 2016, but is still ongoing in many countries.