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The quantification of a biological cell's intrinsic cellular noise can be quantified upon applying Deming regression to the observed behavior of a two reporter synthetic biological circuit. [ 8 ] When humans are asked to draw a linear regression on a scatterplot by guessing, their answers are closer to orthogonal regression than to ordinary ...
In physical experiments uncertainty analysis, or experimental uncertainty assessment, deals with assessing the uncertainty in a measurement.An experiment designed to determine an effect, demonstrate a law, or estimate the numerical value of a physical variable will be affected by errors due to instrumentation, methodology, presence of confounding effects and so on.
Taking into account uncertainty arising from different sources, whether in the context of uncertainty analysis or sensitivity analysis (for calculating sensitivity indices), requires multiple samples of the uncertain parameters and, consequently, running the model (evaluating the -function) multiple times. Depending on the complexity of the ...
Variance-based sensitivity analysis (often referred to as the Sobol’ method or Sobol’ indices, after Ilya M. Sobol’) is a form of global sensitivity analysis. [1] [2] Working within a probabilistic framework, it decomposes the variance of the output of the model or system into fractions which can be attributed to inputs or sets of inputs.
Any non-linear differentiable function, (,), of two variables, and , can be expanded as + +. If we take the variance on both sides and use the formula [11] for the variance of a linear combination of variables (+) = + + (,), then we obtain | | + | | +, where is the standard deviation of the function , is the standard deviation of , is the standard deviation of and = is the ...
It has also been called Sen's slope estimator, [1] [2] slope selection, [3] [4] the single median method, [5] the Kendall robust line-fit method, [6] and the Kendall–Theil robust line. [7] It is named after Henri Theil and Pranab K. Sen , who published papers on this method in 1950 and 1968 respectively, [ 8 ] and after Maurice Kendall ...
Confidence bands can be constructed around estimates of the empirical distribution function.Simple theory allows the construction of point-wise confidence intervals, but it is also possible to construct a simultaneous confidence band for the cumulative distribution function as a whole by inverting the Kolmogorov-Smirnov test, or by using non-parametric likelihood methods.
Uncertainty propagation is the quantification of uncertainties in system output(s) propagated from uncertain inputs. It focuses on the influence on the outputs from the parametric variability listed in the sources of uncertainty. The targets of uncertainty propagation analysis can be: