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Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. [9] It can be taken by mouth or by injection into a vein. [1] [10] It is also available in the fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid [11] [12] and as Konvomep. [13]
Most of these medications are benzimidazole derivatives, related to omeprazole, but imidazopyridine derivatives such as tenatoprazole have also been developed. [77] Potassium-competitive inhibitors such as revaprazan reversibly block the potassium-binding site of the proton pump, acting more quickly, but are not available in most countries.
A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]
However, it has yet to break into the brand-name market of drugs still under patent. ... Other drugs with major savings include Omeprazole-Sodium Bicarbonate (a Proton-pump inhibitor), Dimethyl ...
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
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English: Skeletal formula of omeprazole (original brand names Losec and Prilosec)—a widely used proton pump inhibitor. Created with ChemDoodle 8.0.0.3b and Adobe Illustrator CC 2015 . Date
Jennifer Grey looked back on how a sex scene with Patrick Swayze — that was ultimately cut from 1984’s Red Dawn — was derailed by him being drunk, and her "smoking a lot of weed" at the time ...
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