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The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis. Multiple ETS factors have been found to be associated with cancer, such as through gene fusion.
ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
2313 14247 Ensembl ENSG00000151702 ENSMUSG00000016087 UniProt Q01543 P26323 RefSeq (mRNA) NM_001167681 NM_001271010 NM_001271012 NM_002017 NM_008026 RefSeq (protein) NP_001161153 NP_001257939 NP_001257941 NP_002008 NP_001161153.1 NP_032052 Location (UCSC) Chr 11: 128.69 – 128.81 Mb Chr 9: 32.33 – 32.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Friend leukemia integration 1 ...
This is a list of gene families or gene complexes, i.e. sets of genes which are related ancestrally and often serve similar biological functions.These gene families typically encode functionally related proteins, and sometimes the term gene families is a shorthand for the sets of proteins that the genes encode.
EN1 (gene) EN2 (gene) Eomesodermin; EPAS1; ERF (gene) ERG (gene) ERV3; Estrogen receptor alpha; Estrogen receptor beta; Estrogen-related receptor alpha; Estrogen-related receptor beta; Estrogen-related receptor gamma; Ethylene-responsive element binding protein; ETS transcription factor family; Ets variant 2; Ets variant 5; ETS1; ETS2; ETV1 ...
2002 13712 Ensembl ENSG00000126767 ENSMUSG00000009406 UniProt P19419 P41969 RefSeq (mRNA) NM_005229 NM_001114123 NM_001257168 NM_007922 RefSeq (protein) NP_001107595 NP_001244097 NP_005220 NP_031948 Location (UCSC) Chr X: 47.64 – 47.65 Mb Chr X: 20.8 – 20.82 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1 ...
ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
The FET protein family (also known as the TET protein family) [1] consists of three similarly structured and functioning proteins. [2] They and the genes in the FET gene family which encode them (i.e. form the pre-messenger RNAs that are converted to the messenger RNAs responsible for their production) are: [2] [3] 1) the EWSR1 protein encoded by the EWSR1 gene (also termed the Ewing sarcoma ...
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