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ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene. [ 5 ] [ 6 ] [ 7 ]
TTRAP has been shown to interact with ETS1, [1] TNFRSF1B [2] and CD40. [2] ... This gene encodes a member of a superfamily of divalent cation-dependent ...
Each stage of differentiation is dependent on expression of different transcription factors, including: NFIL3, TCF-1, ETS1, GATA3, PLZF, T-bet, Eomes, RUNX3, RORα, Bcl11b, Gfi1, RORγt, and AhR. [6] The coordinated expression of these specific transcription factors activate or repress target genes critical in the differentiation of the ...
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A neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons.It allows detection and identification of cells by using different techniques.
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