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ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
Each eukaryotic ribosomal cluster contains the 5' external transcribed spacer (5' ETS), the 18S rRNA gene, the ITS1, the 5.8S rRNA gene, the ITS2, the 26S or 28S rRNA gene, and finally the 3' ETS. [5] During rRNA maturation, ETS and ITS pieces are excised. As non-functional by-products of this maturation, they are rapidly degraded. [6]
EWS/Fli-1 may steer clinically important genes via interaction with enhancer-like GGAA-microsatellites. [9] The importance of Fli-1 in the development of human leukemia, such as acute myelogenous leukemia ( AML ), has been demonstrated in studies of translocation involving the Tel transcription factor, which interacts with Fli-1 through protein ...
SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM] [6]
11545 Ensembl ENSG00000143799 ENSMUSG00000026496 UniProt P09874 P11103 RefSeq (mRNA) NM_001618 NM_007415 RefSeq (protein) NP_001609 NP_001609.2 n/a Location (UCSC) Chr 1: 226.36 – 226.41 Mb Chr 1: 180.4 – 180.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD + ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an ...
Zillow's top 10 hottest housing markets of 2025. The primary reasons Buffalo was number one again, according to Zillow? Job and wage growth, relative affordability and demand that outweighs supply.
Spacer DNA is a region of non-coding DNA between genes. [1] [2] The terms intergenic spacer (IGS) or non-transcribed spacer (NTS) are used particularly for the spacer DNA between the many tandemly repeated copies of the ribosomal RNA genes. [3] In bacteria, spacer DNA sequences are only a few nucleotides long.
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