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  2. Narcolepsy - Wikipedia

    en.wikipedia.org/wiki/Narcolepsy

    Narcolepsy type 1 (NT1) can be clinically characterized by symptoms of EDS and cataplexy, and/or will have cerebrospinal fluid (CSF) orexin levels of less than 110 pg/ml. Cataplexy are transient episodes of aberrant tone, most typically loss of tone, that can be associated with strong emotion. [4]

  3. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  4. Sleep disorder - Wikipedia

    en.wikipedia.org/wiki/Sleep_disorder

    Sleep paralysis, characterized by temporary paralysis of the body shortly before or after sleep. Sleep paralysis may be accompanied by visual, auditory or tactile hallucinations. It is not a disorder unless severe, and is often seen as part of narcolepsy.

  5. Excessive daytime sleepiness - Wikipedia

    en.wikipedia.org/wiki/Excessive_daytime_sleepiness

    Narcolepsy, idiopathic hypersomnia, circadian rhythm sleep disorder, sleep apnea, others Excessive daytime sleepiness ( EDS ) is characterized by persistent sleepiness and often a general lack of energy, even during the day after apparently adequate or even prolonged nighttime sleep.

  6. Autosomal dominant cerebellar ataxia, deafness, and narcolepsy

    en.wikipedia.org/wiki/Autosomal_dominant...

    Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCADN) is a rare progressive genetic disorder that primarily affects the nervous system and is characterized by sensorineural hearing loss, narcolepsy with cataplexy, and dementia later in life.

  7. Cataplexy - Wikipedia

    en.wikipedia.org/wiki/Cataplexy

    Narcolepsy with cataplexy is considered an autoimmune-mediated disorder, so some therapies based on this hypothesis have been developed. Immunological therapies developed include: [ 20 ] Corticosteroids : after testing in 1 human and 1 canine case it proved to be ineffective so is less likely to be further used.

  8. Clinical neurochemistry - Wikipedia

    en.wikipedia.org/wiki/Clinical_neurochemistry

    Narcolepsy is a condition characterized by abnormal transitions between REM and non-REM cycles during sleep and the awake cycle. Cataplexy, on the other hand, is an involuntary loss of muscle tone during wakefulness.

  9. CHKB (gene) - Wikipedia

    en.wikipedia.org/wiki/CHKB_(gene)

    Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis.

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