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There are numerous causes of palpable purpura, such as autoimmune diseases, drug reactions, vaccinations, and infections.The most common infectious causes are N. gonorrhoeae, S. aureus, and N. meningitides, however palpable purpura has also been caused by Mycoplasma spp., Rickettsiae, Mycobacterium, and very rarely by Treponema pallidum, Brucella spp., Yersinia, Campylobacter, and Bartonella.
IgA vasculitis (HSP), previously known as Henoch–Schönlein purpura, is an autoimmune disease that most commonly affects children.In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain.
Purpura (/ ˈ p ɜːr p jʊər ə / [1]) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. [2]
Once fully developed, the classic appearance is "non-blanching, palpable purpura". [6] [5] [7] This appears as deep red to purple spots that feel raised to the touch. Purpura refers to the red-purple discolored spots, while palpable implies that these spots can be felt as raised from the surrounding skin.
Individual purpura measure 3–10 mm (0.3–1 cm, 3 ⁄ 32-3 ⁄ 8 in), whereas petechiae measure less than 3 mm. [2] A non-blanching rash can be a symptom of bacterial meningitis , [ 3 ] but this is not the exclusive cause.
A rash is a change of the skin that affects its color, appearance, or texture.. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cracked or blistered, swell, and may be painful.
Such lesions include petechia (less than 3 mm (0.12 in), resulting from numerous and diverse etiologies such as adverse reactions from medications such as warfarin, straining, asphyxiation, platelet disorders and diseases such as cytomegalovirus); [6] and purpura (3–10 mm (0.12–0.39 in)), classified as palpable purpura or non-palpable ...
Although it causes fever, large palpable purpuric skin lesions, and edema, it is a harmless condition. AHEI's appearance is frequently similar to that of Henoch-Schönlein purpura. Because AHEI is a self-limiting disease, conservative treatment is common. [2] Snow described acute hemorrhagic edema of infancy in the United States in 1913.