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Optimal bone health is characterized by adequate bone mineral density (BMD) and proper bone microarchitecture, which together contribute to bone strength. [2] Osteoporosis, a skeletal disorder characterized by compromised bone strength and increased risk of fractures, is a major concern in bone health, particularly among older adults.
[37] [26] Microcrystalline hydroxyapatite, a "second-generation" calcium supplement derived from bovine bone, is claimed by manufacturers to be free of these heavy metals. This supplement comprises an organic component, including collagen and bone-specific growth peptides, and an inorganic component providing calcium and phosphorus.
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid [5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. [6] Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent.
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