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H-type fold pseudoknots are best characterized. In H-type fold, nucleotides in the hairpin-loop pair with the bases outside the hairpin stem forming second stem and loop. This causes formation of pseudoknots with two stems and two loops. [11] Pseudoknots are functional elements in RNA structure having diverse function and found in most classes ...
Nucleic acids consist of a chain of linked units called nucleotides. Each nucleotide consists of three subunits: a phosphate group and a sugar (ribose in the case of RNA, deoxyribose in DNA) make up the backbone of the nucleic acid strand, and attached to the sugar is one of a set of nucleobases.
[12] A section of DNA. The bases lie horizontally between the two spiraling strands [15] (animated version). The DNA double helix is stabilized primarily by two forces: hydrogen bonds between nucleotides and base-stacking interactions among aromatic nucleobases. [16] The four bases found in DNA are adenine (A), cytosine (C), guanine (G) and ...
The term nucleic acid is the overall name for DNA and RNA, members of a family of biopolymers, [13] and is a type of polynucleotide. Nucleic acids were named for their initial discovery within the nucleus , and for the presence of phosphate groups (related to phosphoric acid). [ 14 ]
The DNA double helix biopolymer of nucleic acid is held together by nucleotides which base pair together. [3] In B-DNA, the most common double helical structure found in nature, the double helix is right-handed with about 10–10.5 base pairs per turn. [4] The double helix structure of DNA contains a major groove and minor groove.
Given the difference in widths of the major groove and minor groove, many proteins which bind to DNA do so through the wider major groove. [6] Many double-helical forms are possible; for DNA the three biologically relevant forms are A-DNA, B-DNA, and Z-DNA, while RNA double helices have structures similar to the A form of DNA.
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The double helix is the dominant tertiary structure for biological DNA, and is also a possible structure for RNA. Three DNA conformations are believed to be found in nature, A-DNA, B-DNA, and Z-DNA. The "B" form described by James D. Watson and Francis Crick is believed to predominate in cells. [2]