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Vitamin B 12 is absorbed by a B 12-specific transport proteins or via passive diffusion. [12] Transport-mediated absorption and tissue delivery is a complex process involving three transport proteins: haptocorrin (HC), intrinsic factor (IF) and transcobalamin II (TC2), and respective membrane receptor proteins. HC is present in saliva.
Because vitamin B 12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B 12, and Vitamin B 12 is acid-sensitive, when vitamin B 12 binds to Haptocorrin it can safely pass through ...
[4]: 44 Vitamin B 12 is an essential water-soluble vitamin, the deficiency of which creates anemia (macrocytic anemia), decreased bone marrow cell production (anemia, pancytopenia), neurological problems, as well as metabolic issues (methylmalonyl-CoA acidosis). [4]: 50–51 Vitamin B 12 is therefore an important vitamin for the body to absorb.
Pernicious anemia, or Addison's anemia, is an autoimmune disease which decreases red blood cell count, caused by the body's inability to properly absorb vitamin B12. It can cause diarrhea, pale ...
Vitamin B12 does also accumulate in a few plant-based sources, including some mushrooms, seaweed, and nutritional yeast, but not enough to fortify vegans, who, in particular, should consider being ...
Vitamin B12 and bile salts are absorbed in the terminal ileum. Vitamin B12 will only be absorbed by the ileum after binding to a protein known as intrinsic factor. Water is absorbed by osmosis and lipids by passive diffusion throughout the small intestine. Sodium bicarbonate is absorbed by active transport and glucose and amino acid co-transport
Potential deficiencies linked to hair health include vitamins B12, D, E, A, and biotin, riboflavin, folate, zinc, and iron. ... “Vitamin C is a water-soluble vitamin which has antioxidant ...
Hydroxocobalamin, also known as vitamin B 12a and hydroxycobalamin, is a vitamin found in food and used as a dietary supplement. [1] As a supplement it is used to treat vitamin B12 deficiency including pernicious anemia. [1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
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