Search results
Results from the WOW.Com Content Network
The C.elegans provided as a model organism that allowed researchers to compare the ortholog genes in the programmed cell death pathway. [8] The ortholog of ced-3 gene is caspase 9 and its mutated form is involved in the origin of certain cancers and tumourous tissues. [ 12 ]
Cell death abnormality gene 9 (CED-9), also known as apoptosis regulator CED-9, is a gene found in Caenorhabditis elegans that inhibits/represses programmed cell death . [1] The gene was discovered while searching for mutations in the apoptotic pathway after the discovery of the apoptosis promoting genes CED-3 and CED-4. [2]
The adult C. elegans hermaphrodite has 959 somatic cells and the male has 1033 cells, [56] [57] [58] although it has been suggested that the number of their intestinal cells can increase by one to three in response to gut microbes experienced by mothers. [59]
Regarding the activation of caspases, there exists a gene called ced-9 in C. elegans that protects against cell death that is a part of the Bcl-2 family. ced-9 encodes a protein that is structurally similar to Bcl-2 that binds to another protein ced-4, a homolog of APAF-1 in humans, and prevents it from activating caspase ced-3, which is necessary for killing of the cell. [4]
CED-12 binds CED-2 (C. elegans homolog to CrkII in mammals), followed by CED-5 (C. elegans homolog for DOCK180 in mammals) and forms a ternary structure. [5] [9] Transmembrane CED-1 is an example of the cell-surface receptor on the engulfing cell. When receptors come in contact with cell surface markers on the apoptotic cell, a protein known as ...
One aspect of the cell lineage particularly caught my attention: in addition to the 959 cells generated during worm development and found in the adult, another 131 cells are generated but are not present in the adult. These cells are absent because they undergo programmed cell death - Horvitz: "Worms, Life and Death," 2002. [1]
Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM (born May 8, 1947) is an American biologist whose research on the nematode worm Caenorhabditis elegans [3] [1] was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important ...
She identified the proteins ced-3 and ced-4 as drivers behind programmed cell death in C. elegans, and subsequently identified the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1.