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The common biomolecular mechanisms underlying addiction – CREB and ΔFosB – were reviewed by Eric J. Nestler in a 2013 review. [3] Genetics and mental disorders may precipitate the severity of a drug addiction. It is estimated that 50% of healthy individuals developing an addiction can trace the cause to genetic factors. [4]
One form of behavioral neuropharmacology focuses on the study of drug dependence and how drug addiction affects the human mind. Most research has shown that the major part of the brain that reinforces addiction through neurochemical reward is the nucleus accumbens. The image to the right shows how dopamine is projected into this area.
Arnold Washton has specialized in addiction since 1975 and is an addiction psychologist known for his work in the development of therapeutic approaches to the treatment of drug and alcohol abuse. He is the author of many books and professional journal articles on treatment and addiction.
CNS Productions is a publisher of educational materials — primarily textbooks and instructional DVDs — dealing with psychoactive drugs and addiction.It was formed in 1983 by Paul Steinbroner, with long-time collaborator William E. Cohen who had an extensive background in medical film production.
ΔFosB is the most significant gene transcription factor in addiction since its viral or genetic overexpression in the nucleus accumbens is necessary and sufficient for many of the neural adaptations and behavioral effects (e.g., expression-dependent increases in self-administration and reward sensitization) seen in drug addiction.
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In cases of addiction, particular drugs may affect the brain’s rewards system, making it overly sensitive to the drug: thus making naturally occurring, healthy behaviors less rewarding and increasing deviant behaviors like attention-seeking, impulsivity, and aggression–often related to withdrawal behavioral traits–all of which can promote ...
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